A recently published Japanese study conducted by university oncologists shows improved outcomes for certain mesothelioma patients who undergo near-infrared irradiation treatment used in combination with a cancer-targeting compound. The experiment, which was conducted on laboratory mice, as well as human cells with malignant mesothelioma found that near-infrared photoimmunotherapy was an effective and low-risk method for killing cancer cells without harming the surrounding tissues.
Conducted by Nagoya University, the treatment on the subjects utilized a cancer-targeting antibody compound, designed to a specific structure on the cancer cells, and a photo-absorber called IR700. When the near-infrared light is shone on the cancer-infected part of the body, the antibody compound aggregates on the membranes of the tumor cells, which ruptures the cells and kills the tumor.
“The lungs and chest cavity contain a large amount of air and are thus very good at effectively transmitting near-infrared light,” says Kazuhide Sato of Nagoya University. “NIR-PIT is a safe phototherapy option that can target a region of interest. The antibody-IR700 conjugate is also non-toxic to the body in the absence of near-infrared light irradiation. We thus thought that NIR-PIT could be an effective strategy for controlling localized MPM.”